Absolute configuration of (+)-?-dihydrotetrabenazine, an active metabolite of tetrabenazine
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چکیده
منابع مشابه
Absolute Configuration of (+)--Dihydrotetrabenazine, an Active Metabolite of Tetrabenazine
Chiral column liquid chromatography and enantiospecific enzymatic hydrolysis were utilized to separate the enantiomers of aand b-dihydrotetrabenazine and a-9-O-desmethyldihydrotetrabenazine, three benzo[a]quinolizines derived from the amine-depleting drug tetrabenazine. An X-ray crystal structure analysis of (−)-a-9-Odesmethyldihydrotetrabenazine gave an absolute structure of that compound as t...
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ژورنال
عنوان ژورنال: Chirality
سال: 1997
ISSN: 0899-0042,1520-636X
DOI: 10.1002/(sici)1520-636x(1997)9:1<59::aid-chir11>3.0.co;2-p